Monkeypox is a zoonotic viral disease. Media campaigns are planned to create awareness about the disease. This is because mass media is often the leading source of information and mobilization during important health issues or crisis. The main objective of this study was to assess the media coverage of monkeypox outbreak in Nigeria.The study adopted a cross-sectional survey of residents in Southern Nigeria. A total of 600 respondents were sampled for this study through a multi-stage cluster random sampling technique. Research assistants helped in collecting data from respondents through structured questionnaire. The data collected was analyzed using percentages, mean score, and univariate analysis of variance (ANOVA).Respondents had little or no knowledge of monkeypox virus, its nature, mode of transmission, and prevention mechanism (2.30 ± .918, P = .000). Respondents stated that they learnt about the virus through friends and social institutions instead of media (4.44 ± .945, P = .006). Media failed to create effective and comprehensive awareness campaigns to mobilize the public (1.86 ± 1.196, P = .001), while inappropriate and insufficient media programs and lack of funds were blamed for media ineffectiveness (4.18 ± 1.352, P = .004).The outbreak of monkeypox virus is a public health concern in Nigeria. Media campaigns are planned to raise awareness about the disease; however, these campaigns have not demonstrated effectiveness in changing people's health behavior toward monkeypox. Media, health professionals, and government should synergize to promote a consistent health policy for the control and prevention of monkeypox virus.