The purpose of this study was to assess the amount of variance in the coping strategies of patients with brain tumors that could be accounted for by resilience.This cross-sectional survey involved 95 patients who had experienced surgical, chemotherapy, or radiotherapy therapies for their brain tumors at least one month prior to data collection. The investigator collected data using the scales of the Ways of Coping Checklist-Revised (WCC-R) and Resilience Scale (RS). Data were analyzed using descriptive statistics, t-tests, analysis of variance, Pearson product-moment correlation, and hierarchical multiple regression.The results revealed that resilience was significantly positively associated with patients' problem-focused coping (r = .65, p < .001) and total coping (r = .49, p < .001). In addition, resilience accounted for 27% (R = .27, p < .001) and 16% (R = .16, p < .001) of the distinct variances in predicting patients' problem-focused coping and total coping.The current results provide evidence to support the importance of resilience in shaping the coping strategies of relevant patients. As resilience shows a crucial element in patient coping with brain tumors, health team members should develop and employ appropriate strategies to improve the resilience of patients with brain tumors.