The present study aims to investigate the effect of microstructure and texture on mechanical properties of resistance spot welding of high strength steel 22MnB5 and 5A06 aluminium alloy as a function of welding parameters. The pseudo-nugget zones (NZs) at the steel side have undergone full recrystallisation with a fine-grained ferrite structure containing a small amount of retained austenite and a high hardness of approximately 500 HV, which is a 35% increase in hardness compared to the base material (BM) with fine lath martensitic structure. The NZs at the Al side contain both a recrystallisation texture and shear texture. Higher tensile shear strength with increasing weld time could be linked to the random texture at the Al side. The highest tensile shear strength was achieved at an intermetallic layer thickness of 4 mm.