Comprehensive investigations designate to study the working conditions and health status of workers of asphalt-bitumen plants were conducted. Measurable in the breathing zone of workers of basic professions were toxic substances that have a toxic effect on the body (benzene, oil hydrocarbons, toluene, nitric, carbonic oxides, and benz(a)pyrene). There was noted a high incidence of abnormalities of the internal organs, with the cardiovascular and respiratory pathology ranking first in frequency to other disorders. Studies on the allergologic and atopic status showed that as far as the development of the respiratory organ pathology and the external breathing functional shifts are concerned, the immunity status-related specificities of the body are to be considered along with in-plant factors. Measures have been designed aimed to prevent the development of disorders.