This study has reported the effects of biogenic silver nanoparticles (AgNPs) using cocoa pod extract on physiological tolerance indices, antioxidant activity and hepatoprotective potentials of Corchorus olitorius as well as its efficiency for controlling soil phytopathogens. C. olitorius seeds were grown in soil prepared with water (control), 0.05, 0.1, 0.15 and 0.2 mg AgNPs/g soil. C. olitorus grown with AgNPs had significantly (p < 0.05) higher free radical scavenging ability, ferric reducing ability, percentage germination, vigour indices, longer roots and shoots as well as lower moisture content over control. C. olitorius grown with AgNPs attenuated hydrogen peroxide (HO)-mediated reduction in catalase concentrations and HO-induced malondialdehyde elevations in liver. Efficiency of AgNPs to reduce soil phytopathogens (fungi and nematodes) revealed significant (p < 0.05) reduction in the incidences of soil and shoot Meloidogyne spp., Aspergillus terreus, A. niger, Fusarium spp. and Cladosporium spp. with increase in concentrations of AgNPs. More efficiently, there was complete extermination of A. niger and Fusarium spp. in the leaves of C. olitorius grown with AgNPs. Results in this study have shown the positive influence of AgNPs on C. olitorius by strengthening its resistance against fungi, and nematodes, improvement of its shelf-life, modulation of antioxidant activities and promotion of liver-detoxifying potentials.