Challenges in Alzheimer Disease Drug Discovery and Development: The Role of Modeling, Simulation and Open Data.
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Challenges in Alzheimer Disease Drug Discovery and Development: The Role of Modeling, Simulation and Open Data.

Conrado, Daniela J;Duvvuri, Sridhar;Geerts, Hugo;Burton, Jackson;Biesdorf, Carla;Ahamadi, Malidi;Macha, Sreeraj;Hather, Gregory;Morales, Juan Francisco;Podichetty, Jagdeep;Nicholas, Timothy;Stephenson, Diane;Trame, Mirjam;Romero, Klaus;Corrigan, Brian;, ;
clinical pharmacology and therapeutics 2020
359
conrado2020challengesclinical

Abstract

Alzheimer disease (AD) is the leading cause of dementia worldwide. With 35 million people over 60 years of age with dementia, there is an urgent need to develop new treatments for AD. To streamline this process, it is imperative to apply insights and learnings from past failures to future drug development programs. In the present work, we focus on how modeling and simulation (M&S) tools can leverage open data to address drug development challenges in AD.

Keywords

Simulation alzheimer disease modeling open data open science challenges drug discovery drug development novel technologies

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DOI:
10.1002/cpt.1782

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ID: 84448
Ref Key: conrado2020challengesclinical
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