The present study investigated the effects of enterocin (Ent) M and sage extract alone and also in combination on the gut microflora, phagocytic activity, blood biochemistry, and morphometry of rabbits. Sixty-four rabbits (aged five weeks, M91 meatline, both sexes) were divided into three experimental groups: E (EntM; 50 µL/animal/day), S (sage; 10 µL/animal/day), and E + S (EntM + sage) groups and control group (C). The additives were administered in drinking water for a period of 21 days. Dietary supplementation of EntM and sage significantly reduced the coliforms (E: < 0.001; S: < 0.001; E + S: < 0.001) in feces, while simultaneous addition of EntM and sage decreased enterococci (E + S: < 0.0001), lactic acid bacteria (E + S: < 0.01), and coagulase-positive staphylococci (E + S: < 0.0001) in the appendix. Sage addition reduced HDL (S: < 0.001) and LDL cholesterol (S: < 0.001; E + S: < 0.001), LDL/HDL ratio (S: < 0.001; E + S: < 0.01), and increased urea (S: < 0.01; E + S: < 0.001) and creatinine (S: < 0.001; E + S: < 0.001) in serum. EntM and sage application, alone or in combination, improve the jejunal morphometry ( < 0.0001) in rabbits.