Micropollution such as pharmaceutical residuals potentially compromises water quality and jeopardizes human health. This study evaluated the photo-Fenton ceramic membrane filtration toward the removal of sulfadiazine (SDZ) as a common antibiotic chemical. The batch experiments verified that the photo-Fenton reactions with as Goethite (α-FeOOH) as the photo-Fenton catalyst achieved the degradation rates of 100% within 60 min with an initial SDZ concentration of 12 mg·L. Meanwhile, a mineralization rate of over 80% was obtained. In continuous filtration, a negligible removal rate (e.g., 4%) of SDZ was obtained when only filtering the feed solution with uncoated or catalyst-coated membranes. However, under Ultraviolet (UV) irradiation, both the removal rates of SDZ were significantly increased to 70% (no HO) and 99% (with HO), respectively, confirming the active degradation by the photo-Fenton reactions. The highest apparent quantum yield (AQY) reached up to approximately 25% when the UV intensity was 100 μW·cm and HO was 10 mmol·L. Moreover, the photo-Fenton reaction was shown to effectively mitigate fouling and prevent flux decline. This study demonstrated synchronization of photo-Fenton reactions and membrane filtration to enhance micropollutant degradation. The findings are also important for rationale design and operation of photo-Fenton or photocatalytic membrane filtration systems.