Response to "Reply to: 'The decreasing predictive power of MELD in an era of changing etiology of liver disease'".
Godfrey, Elizabeth L;Malik, Tahir H;Lai, Jennifer C;Mindikoglu, Ayse L;Galván, N Thao N;Cotton, Ronald T;O'Mahony, Christine A;Goss, John A;Rana, Abbas;
american journal of transplantation : official journal of the american society of transplantation and the american society of transplant surgeons2020
333
godfrey2020responseamerican
Abstract
We appreciate Kwong et al.'s utilization of Harrell's c-statistic and its ability to incorporate follow-up time as a valuable contribution to the discussion about our group's findings. We acknowledge that the conventional area under receiver-operating-characteristic curve concordance statistic has limitations; however, we selected the conventional c-statistic to remain methodologically consistent with the manner in which the Model for End-Stage Liver Disease (MELD) was originally designed and validated, first to predict post-TIPS survival, then when applied to ESLD generally, and finally when integrated into allocation.