A few studies have examined mothers' perception of ICT and maternal and child health (MCH) information promoted using ICT. The effectiveness of different modes of delivery of such information is unclear.To investigate mothers' perceived usefulness of ICT and MCH information disseminated through e-health projects in Nigeria.The study was a descriptive survey that was based on the mixed method paradigm. A questionnaire was used to collect data from 1001 mothers involved in ongoing ICT based projects in Nigeria. The mothers were selected using a convenience sampling technique. Four focus group discussion sessions were also organised for thirty mothers.Mobile phones were viewed as useful (35.0%) or very useful (42.2%) and radio as useful (34.8%) or very useful (57.5%%). But they expressed a negative perception towards the use of DVD/TV (Not useful, 66.5%) and the Internet/computer (Not useful 67.7%). Mothers' perception of MCH information disseminated was also positive. They reported the need for more MCH information products in local languages using acceptable ICT.Mothers' perception of preferred modes of delivery of maternal and child health information varies according to location.