The purpose of this study is to examine the role of knowledge management practices in enhancing performance of universities, specifically in the context of Pakistan. A convenient sample of 450 employees from the universities all over the Pakistan was taken for the study. Exploratory factor analysis was performed to identify the elements of knowledge management and linear regression analysis was performed to test the hypotheses presented in the study. This study measures the moderating role of technology in the knowledge management framework. Furthermore, it relied on R&D, employee commitment and industry linkages to construct universities’ performance. The results revealed that knowledge management process and knowledge management infrastructure (HR and culture) are significant predictors of the performance of universities. It was also found that technology moderates the relationship of knowledge management dimensions and universities’ performance. The study highlighted that with proper attention towards knowledge management infrastructure, knowledge management processes and technology, universities can outperform their competitors.