In healthcare system as in hospitals, nurses play integral role to provide all healthcare services in a hospital at its optimum. The nurses’ twenty-four hours availability of services in hospitals has made them the most common healthcare persons. Nurses’ work performance is nurses’ activity in implementing command, tasks, and responsibilities at its best in order to achieve and manifest their professional goals and the organizational unit goals. The purpose of the study is to identify the effects of healthcare allowance compensation received by the nurses and the nurses’ job satisfaction on their own work performance through organizational commitment as the mediating variable. The study applies questionnaire as the instrument to collect data and process the data by applying Structural Equation Model (SEM) to conduct empirical test on model of the study, which is respondents who work as nurses in type-A hospitals in Jakarta area. The results of the study indicate that the healthcare allowance compensation affects the organizational commitment; the job satisfaction affects the organizational commitment; the healthcare allowance compensation does not affect the nurses’ work performance; the job satisfaction affects the nurses’ work performance; the organizational commitment affects the nurses’ work performance; and the organizational commitment mediates the correlation of the healthcare allowance compensation and job satisfaction on the nurses’ work performance.