Experimental design term usually refers to a two-stage modeling. The first of all named as working strategy is the establishment of the experiment execution model in which the operating range of the experimental factors called as working parameters shown the simultaneous changes including their interactions with each other on the reaction. Second step is to determine a linear or nonlinear mathematical model for response surface function to define the relationship between the factors and the experimental result. Predetermination of the experimental factor levels for the experimental works in the laboratory is the most important stage for the creation of experimental strategies. The linear or non-linear mathematical models chosen for the response surface function to define the relationship between the factors and the experimental results may also be as similar complex structure as the models planned for the experiment execution in the working strategy determined.