Geographic location continues to be an important indicator in incidence of, access to treatment for, and mortality from breast cancer. Disparities in access to screening and early detection persist in Appalachian Virginia. We developed an index to identify sites which would most benefit from increased frequency of mobile mammography visits, based on geographically relevant population-level risk factors (late stage of tumor diagnosis) and accessibility risk factors (access to FDA [US Food and Drug Administration] mammography sites, access of women aged 50+ years to primary care physicians at existing mobile sites). These 4 components for the Priority Index were subsequently standardized and multiplied to importance weights. The percentage of mammograms performed in the target geographic region has increased each year, respectively. This article presents methodological considerations for developing a priority algorithm to increase access to breast cancer early screening and detection for vulnerable women.