Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents.
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Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents.

Khandazhinskaya, Anastasia L;Matyugina, Elena S;Solyev, Pavel N;Wilkinson, Maggie;Buckheit, Karen W;Buckheit, Robert W;Chernousova, Larisa N;Smirnova, Tatiana G;Andreevskaya, Sofya N;Alzahrani, Khalid J;Natto, Manal J;Kochetkov, Sergey N;de Koning, Harry P;Seley-Radtke, Katherine L;
Molecules (Basel, Switzerland) 2019 Vol. 24
234
khandazhinskaya2019investigationmolecules

Abstract

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.

Keywords

tuberculosis antiparasitic nucleosides carbocyclic leishmanial mycobacterial

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