Whether duration of chronic total occlusion (CTO) affects lesion and procedural characteristics remains largely unknown.To investigate whether CTO duration influences lesion characteristics and revascularization success.EuroCTO Registry data on patients who had CTO percutaneous coronary intervention between January 2015 and April 2017 were analyzed. Three groups were created based on occlusion age: 3 to 6 months ( = 1415), 7 to 12 months ( = 973), > 12 months ( = 1656).Patients with greater CTO duration were older (63.0 (56.0-70.0); 63.0 (56.0-71.0); 66.0 (59.0-73.0) years respectively; < 0.001), had more 3-vessel disease (32.2%; 30.9%; 46.1% respectively; < 0.001) and more frequent prior coronary artery bypass grafting (8.2%; 9.9%; 29.4% respectively; < 0.001). In multivariate analysis, occlusion duration was associated with moderate/severe calcification (OR = 1.52; 95% CI: 1.28-1.80; < 0.001), lesion length > 20 mm (OR 1.77; 95% CI 1.49-2.10; < 0.001), and collateral circulation Werner type 2 (OR = 1.20; 95% CI: 1.01-1.43; = 0.041). The CTO duration was associated with lower procedural success (OR for success 0.60; 95% CI: 0.46-0.79; < 0.001). In multivariate analysis in-hospital adverse events did not differ according to duration of CTO.Coronary artery CTO duration is associated with greater extent of calcification, lesion length, development of collateral circulation and, most importantly, with lower procedural success.