This study aims to determine the influencing factors of patient safety culture implementation by ward nurses in the hospital.This research used descriptive correlation with cross-sectional approach. The study population was 205 respondents. Data obtained by distributing valid and reliable questionnaires. Univariate and bivariate data were analyzed using chi-square test.The results showed that 60.5% of nurses had good patient safety knowledge. A total of 57.5% of nurses had high motivation and stated that leader behaviors supported patient safety implementation (54.6%). In another hand, 51.2% of nurses said they had implemented patient safety culture. In the next analysis, there was a significant relationship between nurses' knowledge, the motivation of patient safety, and the behavior leaders with its implementation of patient safety culture (p<0.05).This study shows the individual factors influence the implementation of patient's safety culture in hospital.