The Piperaceae family is recognized for its diverse biological properties such as antifungal, antibacterial, cytotoxic and insecticidal activities. Phytochemical investigation of inflorescences from led to the isolation and identification of a new 4-chromanone called oxocumanensic acid, along with five known benzoic acid derivatives. The antifungal activity was evaluated against six phytopathogenic fungi by a mycelium growth inhibition test. All compounds were active against the phytopathogenic fungi, showing a greater activity against fungi of genus. Finally, phytotoxicity was evaluated in the extract and its chemical constituents, finding that the natural substances are less toxic than the positive control.