Safety issues of animal derived food have been emerging one after another, and the using of the illegal addictives and abuse of high-risk chemicals bred for livestock have been increasingly serious from melamine, lean meat powder, Sudan Red, plasticizing agent, waste oils to leather milk. How to determine these chemicals faces severe challenges. Infrared spectroscopy is the same powerful for material structures as nuclear magnetic resonance spectroscopy, mass spectrometry and ultraviolet spectrum. There are few researches about quality and safety of livestocks products. In this article, some researches in analyzing structures has been reviewed, including studies of spectral features, molecular conformation, stability, homologous series, derivative and reaction products, inferring functional groups of macromolecular compounds and molecular structural formula and distinguishing complex biological samples. Forming the new thought screening contaminants maybe used for animals is expected to early warning addictives causing serious food safety problems that is to build the comprehensive analysis methods for these matters on the basis of creating spectrum or functional groups databases designed for animal products.