Sixteen sesquiterpenoids (-), including two new compounds namely saussucostusosides A and B ( and ), were isolated from the roots of by various chromatographic separations. Their structures were elucidated by 1 D and 2 D NMR and HR-QTOF-MS experiments. Among isolated compounds, costunlide (), 3-[4-hydroxymethacryloyloxy]-8-hydroxycostunolide () and 11,13-dihydrozaluzanin C () exhibited potent inhibitory effects on LPS-induced NO production in RAW264.7 cells with IC values of 7.08 ± 0.34, 2.40 ± 0.06 and 5.55 ± 0.24 µM, respectively.