The decreasing performance of jet engines during operation is a major concern for airlines and maintenance companies. Among other effects, the erosion of high-pressure compressor (HPC) blades is a critical one and leads to a changed aerodynamic behavior, and therefore to a change in performance. The maintenance of BLISKs (blade-integrated-disks) is especially challenging because the blade arrangement cannot be changed and individual blades cannot be replaced. Thus, coupled deteriorated blades have a complex aerodynamic behavior which can have a stronger influence on compressor performance than a conventional HPC. To ensure effective maintenance for BLISKs, the impact of coupled misshaped blades are the key factor. The present study addresses these effects on the aerodynamic performance of a first-stage BLISK of a high-pressure compressor. Therefore, a design of experiments (DoE) is done to identify the geometric properties which lead to a reduction in performance. It is shown that the effect of coupled variances is dependent on the operating point. Based on the DoE analysis, the thickness-related parameters, the stagger angle, and the max. profile camber as coupled parameters are identified as the most important parameters for all operating points.