To compare 2-octyl-cyanoacrylate (2-octyl-CA) glue with polyglytone 6211 sutures in circumcision wound closure on the basis of operative time, safeness, postoperative pain and cosmesis.The boys who would undergo circumcision in 18-month period (n = 137) were grouped into two. In Group 1 (n = 64), 6/0 polyglytone 6211 sutures, and in Group 2 (n = 73), 2-octyl-CA glue were used for wound closure. Durations of anesthesia, surgical procedures and postoperative pain, and pain scores on the 2nd and 48th postoperative hours were determined. A classification system was constructed to evaluate cosmesis, intraoperative and postoperative bleeding. Quantitative differences were assessed by Mann-Whitney U and Student's t tests, and qualitative analyses were performed by χ (2) test. p was considered as significant at less than 0.05.The pain scores of the groups were comparable. Durations of anesthesia, surgical procedures and postoperative pain were significantly shorter (p < 0.05); and cosmesis, intraoperative and postoperative bleeding status were significantly better in Group 2 (p < 0.05).2-Octyl-CA seems to be a good alternative to the conventional suturing technique in circumcision wound closure with shorter operation time, ease of appliance, improved safeness, better cosmesis and shorter duration of postoperative pain.