Rwanda's ambitious Human Resources for Health (HRH) program comes to an end this year, having made great strides towards achieving its aim to create a large, diverse and competent health workforce, and will have graduated over 4,500 healthcare professionals since its inception in 2012. The HRH program was based on strong collaborative relationships between Rwandan and United States academic institutions and faculty and now stands poised to enter a new phase focused on sustaining the many gains achieved. Fostering career development of new Rwandan faculty and building health research capacity are key components to sustaining the mutually beneficial partnerships that have been forged over the past seven years, with the goal of creating strong Rwandan health researchers that can advance knowledge of best practices for patient care and public health, appropriate to the Rwandan context and other resource-limited settings.