Although e-health is an area recognized as essential in the rapid development of healthcare systems in low resource contexts, many challenges prevent the emergence of an effective e-health ecosystem. Lack in capacity around health informatics is one of the main challenges. Based on a longitudinal case study gathering data pertaining to a master's program in biomedical informatics in Sri Lanka designed for doctors, in this paper we demonstrate that creating 'hybrid doctors' may be the way forward. We illustrate how hybrid doctors conversant in healthcare and information and communication technology (ICT) are able to facilitate the creation of an e-health ecosystem in a way that it would contribute significantly to the ICT driven healthcare reforms. Through this case study we highlight the importance of multidisciplinarity, participatory design, strategic investments, learning that aligns with developmental needs, networking, gaining legitimacy and re-packaging perspectives on 'health informatics capacity development'.