To evaluate if pancreatic computed tomography (CT) image quality benefits from using individualized vs. fixed post-trigger delay for contrast media timing. In this prospective study CT of the pancreas was performed on one cohort using individualized post-trigger delay and one cohort using fixed post-trigger delay. Except for the post-trigger delays the CT-protocol, contrast media application and image reconstruction were identical in both cohorts. Objective (mean attenuation in HU) and subjective image quality (5-point Likert-scale) were evaluated in the pancreatic head and body. Student's t-test was used to test for differences between cohorts regarding objective image quality while Mann-Whitney-U test and Fisher's exact test were used for subjective image quality. A total of 100 patients were evaluated, of which 50 patients were enrolled in the individualized cohort (mean age: 63 ± 14; 27 male) and 50 patients in the fixed cohort (mean age: 64 ± 16; 26 male). In the individualized cohort mean attenuation was higher (pancreatic head: 126 ± 55 HU vs. 86 ± 63 HU; p < 0.001; body: 125 ± 49 HU vs. 93 ± 55 HU; p = 0.003). Subjective quality was rated higher in the individualized cohort ("excellent" or "good": 84% vs. 30%; p < 0.001). Post-trigger delays in the individualized cohort ranged from 5 to 37 s compared to 20 s in the fixed cohort. Patient demographics and radiation exposure were similar between groups (p > 0.05). Individualized post-trigger delay for contrast media timing in CT improves attenuation of the pancreas. Subjective image quality improves regarding demarcation of the pancreas as well as recognizability of the pancreatic duct, potentially increasing diagnostic reliability.