The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim
Abstract
Eukaryotic mRNAs are exported from the nucleus to the cytoplasm as complex mRNA-protein particles (mRNPs), and translocation through the nuclear pore complex (NPC) is accompanied by extensive structural changes of the mRNP. We have tested the hypothesis that the DEAD-box ATPase Dbp5p is required for …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
N.I.H.
Extramural
mutation
Nuclear Proteins / physiology*
messenger / metabolism
saccharomyces cerevisiae / genetics
cell nucleus / metabolism*
saccharomyces cerevisiae / metabolism
saccharomyces cerevisiae proteins / physiology*
saccharomyces cerevisiae proteins / genetics
active transport
cell nucleus / physiology
pmid:16307927
doi:10.1016/j.molcel.2005.10.005
mette k lund
christine guthrie
dead-box rna helicases
nucleocytoplasmic transport proteins / genetics
nucleocytoplasmic transport proteins / physiology*
rna helicases / genetics
rna helicases / physiology*
rna-binding proteins / physiology*
ribonucleoproteins / metabolism*
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284547
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