Low Prevalence of ETV6::RUNX1 Fusion Gene in a Hispanic Population
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Low Prevalence of ETV6::RUNX1 Fusion Gene in a Hispanic Population

Mata-Rocha, Minerva;Rangel-López, Angelica;Jimenez-Hernandez, Elva;Nuñez-Enríquez, Juan Carlos;Morales-Castillo, Blanca Angélica;Sánchez-Escobar, Norberto;Sánchez-Escobar, Norberto;Sepúlveda-Robles, Omar Alejandro;Bravata-Alcántara, Juan Carlos;Nájera-Cortés, Alan Steve;Pérez-Saldivar, María Luisa;Flores-Lujano, Janet;Duarte-Rodríguez, David Aldebarán;Anda, Norma Angélica Oviedo de;Tlalolini, Maria de los Angeles Romero;Verson, Carmen Alaez;Martín-Trejo, Jorge Alfonso;Medina, Jose Esteban Muñoz;Gonzalez-Bonilla, Cesar Raul;Cueto, Maria de los Angeles Hernandez;Bekker-Méndez, VC.;Jiménez-Morales, Silvia;Medina-Sansón, Aurora;Amador-Sánchez, Raquel;Peñaloza-González, José Gabriel;Torres-Nava, José Refugio;Espinosa-Elizondo, Rosa Martha;Cortés-Herrera, Beatriz;Flores-Villegas, Luz Victoria;Merino-Pasaye, Laura Elizabeth;Gutierrez-Rivera, Maria de Lourdes;Velazquez-Aviña, Martha Margarita;Santillan-Juarez, Jessica Denisse;Gurrola-Silva, Alma;Echáurregui, Gabriela Alicia Hernández;Hidalgo-Miranda, Alfredo;Galindo, José Arellano;Rosas-Vargas, Haydeé;Mejía-Aranguré, Juan Manuel;Mejía-Aranguré, Juan Manuel;Mejía-Aranguré, Juan Manuel;
frontiers in pediatrics 2022 Vol. 10 pp. -
44
matarocha2022lowfrontiers

Abstract

ETV6::RUNX1 is a genetic rearrangement of good prognosis in children with acute lymphoblastic leukemia (ALL). In Mexico, its prevalence is low in comparison with Caucasian populations. We developed a novel TaqMan one-step RT-qPCR approach to assess the prevalence of four genetic rearrangements in a cohort of Hispanic children with ALL from Mexico City. The prevalence of common fusion gene transcripts was as follows: TCF3::PBX1 7.7%; BCR::ABL1p190 3.3%; and KMT2A::AFF1 2.8%, and ETV6::RUNX1was observed with low prevalence (10.5%) in comparison to that reported for developed countries. This is consistent with previous findings on Mexican children with ALL and similar to those reported on children from Hispanic populations. The confirmation of a low prevalence of ETV6::RUNX1 in children of a Hispanic origin represents an advancement in the description of genetic factors of ALL in these populations.

Keywords

Nursing Education Medicine (General) Pediatrics public aspects of medicine economic history and conditions social history and conditions. social problems. social reform electronic computers. computer science computer software

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