Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6
Abstract
Transcription factors GATA-4, -5, and -6 constitute an evolutionary conserved subfamily of vertebrate zinc finger regulators highly expressed in the developing heart and gut. Genetic evidence suggests that each protein is essential for embryonic development, but their exact functions are not fully e …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
cell line
polymerase chain reaction
Base Sequence
DNA-Binding Proteins / physiology*
transcription factors / metabolism
immunohistochemistry
embryo
dna primers
transcription factors / physiology*
dna-binding proteins / metabolism
transcriptional activation*
bone morphogenetic proteins / genetics*
bone morphogenetic protein 4
pmid:12606287
doi:10.1016/s0012-1606(02)00026-x
georges nemer
mona nemer
mammalian / metabolism*
gata4 transcription factor
gata6 transcription factor
organogenesis / physiology*
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274634
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