Age-Related Loss of Cohesion: Causes and Effects
Abstract
Aneuploidy is a leading genetic cause of birth defects and lower implantation rates in humans. Most errors in chromosome number originate from oocytes. Aneuploidy in oocytes increases with advanced maternal age. Recent studies support the hypothesis that cohesion deterioration with advanced maternal …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
female
male
chromosomes
human* / genetics
anaphase / genetics*
pmid:28737671
pmc5536066
doi:10.3390/ijms18071578
jin-mei cheng
yi-xun liu
aging* / genetics
aging* / metabolism
aging* / pathology
aneuploidy*
chromatids* / genetics
chromatids* / metabolism
chromosome segregation / genetics*
human* / metabolism
oocytes / pathology
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274599
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