BRCA1/BARD1 inhibition of mRNA 3′ processing involves targeted degradation of RNA polymerase II

BRCA1/BARD1 inhibition of mRNA 3′ processing involves targeted degradation of RNA polymerase II

Frida E. Kleiman, Foon Wu-Baer, Danae Fonseca, Syuzo Kaneko, Richard Baer, James L. Manley;Frida E. Kleiman;Foon Wu-Baer;Danae Fonseca;Syuzo Kaneko;Richard Baer;James L. Manley;
genes & development 2005 Vol. 19 pp. 1227-
168
manley2005genesbrca1/bard1

Abstract

Mammalian cells exhibit a complex response to DNA damage. The tumor suppressor BRCA1 and associated protein BARD1 are thought to play an important role in this response, and our previous work demonstrated that this includes transient inhibition of the ...

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