PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer
Abstract
Prostate cancer (PrCa) is characterized by progression from an androgen-dependent phenotype to one that is inevitably androgen independent (AI) and lethal. Recent evidence strongly suggests that the phosphatidylinositol-3-kinase/Akt (PI3K/Akt) and androgen receptor (AR) signalling pathways provide p …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
humans
pubmed abstract
nih
national institutes of health
national library of medicine
male
disease progression
androgens / physiology*
pmid:16421604
doi:10.1038/sj.onc.1209020
d j mulholland
s dedhar
c c nelson
glycogen synthase kinase 3 / physiology*
glycogen synthase kinase 3 beta
pten phosphohydrolase / physiology*
prostatic neoplasms / physiopathology*
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274468
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