Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design
Abstract
The development and clinical use of 4-aminoquinoline antimalarial agents such as amodiaquine have been limited by toxicity to neutrophils. We have investigated the chemical basis of amodiaquine-induced toxicity and compared the findings with those for established antimalarial drugs proposed for huma …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
in vitro techniques
leukocytes
cell survival / drug effects
molecular structure
structure-activity relationship
tetradecanoylphorbol acetate / pharmacology
drug design
tritium
mononuclear / metabolism*
neutrophils / pathology
pmid:9023303
d j naisbitt
j e ruscoe
b k park
amodiaquine / analogs & derivatives*
amodiaquine / blood*
amodiaquine / pharmacokinetics
amodiaquine / toxicity
antimalarials / blood*
antimalarials / pharmacokinetics
antimalarials / toxicity
glutathione / blood
mononuclear / drug effects
mononuclear / pathology
neutrophils / drug effects
neutrophils / metabolism*
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274238
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274238
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