Regulation of leptin promoter function by Sp1, C/EBP, and a novel factor
Abstract
Leptin is a hormone produced in adipose cells that regulates energy expenditure, food intake, and adiposity. To understand leptin's transcriptional regulation, we are studying its promoter. Four conserved and functional regions were identified. Mutations in the C/EBP and TATA motifs each caused an a …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Adipocytes / metabolism
Rats
genetic*
CCAAT-Enhancer-Binding Proteins
Receptors
Base Sequence
Molecular Sequence Data
DNA-Binding Proteins / physiology*
Nuclear Proteins / physiology*
Promoter Regions
proteins / genetics*
hela cells
binding sites
transcription factors / physiology
cytoplasmic and nuclear / physiology
sterol regulatory element binding protein 1
point mutation
leptin
sp1 transcription factor / physiology*
pmid:9492033
doi:10.1210/endo.139.3.5792
m m mason
y he
m reitman
zucker
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274135
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