Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice
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Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice

Shereen Nizari, Jack A. Wells, Roxana O. Carare, Ignacio A. Romero, Cheryl A. Hawkes;Shereen Nizari;Jack A. Wells;Roxana O. Carare;Ignacio A. Romero;Cheryl A. Hawkes;
acta neuropathologica communications 2021 Vol. 9 pp. -
174
hawkes2021actaloss

Abstract

Vascular dysregulation and cholinergic basal forebrain degeneration are both early pathological events in the development of Alzheimer’s disease (AD). Acetylcholine contributes to localised arterial dilatation and increased cerebral blood flow ...

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DOI:
10.1186/s40478-020-01108-z
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC77918...

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