p53 and microRNA-34 are suppressors of canonical Wnt signaling
Abstract
Although loss of p53 function and activation of canonical Wnt signaling cascades are frequently coupled in cancer, the links between these two pathways remain unclear. We report that p53 transactivated microRNA-34 (miR-34), which consequently suppressed the transcriptional activity of β-catenin-T ce …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
N.I.H.
Extramural
Child
Cells
Cultured
cell line
Base Sequence
mutation
Gene Expression Regulation*
gene expression profiling
breast neoplasms / pathology
embryo
rna interference
micrornas / metabolism
hek293 cells
beta catenin / metabolism
micrornas / genetics*
chick embryo
tumor suppressor protein p53 / metabolism
wnt1 protein / genetics
wnt1 protein / metabolism
3' untranslated regions / genetics
xenopus laevis
breast neoplasms / genetics
breast neoplasms / metabolism
pmid:22045851
pmc3447368
doi:10.1126/scisignal.2001744
nam hee kim
hyun sil kim
stephen j weiss
nonmammalian / embryology
nonmammalian / metabolism
neuroblastoma / genetics
neuroblastoma / metabolism
neuroblastoma / pathology
tcf transcription factors / genetics
tcf transcription factors / metabolism
tumor suppressor protein p53 / genetics*
wnt signaling pathway / genetics*
beta catenin / genetics
Citation
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273677
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