Roles for Nkx3.1 in prostate development and cancer

Roles for Nkx3.1 in prostate development and cancer

Bhatia-Gaur R;Donjacour AA;Sciavolino PJ;Kim M;Desai N;Young P;Norton CR;Gridley T;Cardiff RD;Cunha GR;Abate-Shen C;Shen MM;;
genes & development 1999 Vol. 13 pp. -
229
r1999genesroles

Abstract

In aging men, the prostate gland becomes hyperproliferative and displays a propensity toward carcinoma. Although this hyperproliferative process has been proposed to represent an inappropriate reactivation of an embryonic differentiation program, the regulatory genes responsible for normal prostate …

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