Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani
Abstract
To determine the relative contributions of respiratory burst-derived reactive oxygen intermediates (ROI) versus reactive nitrogen intermediates (RNI) to macrophage-mediated intracellular host defense, mice genetically deficient in these mechanisms were challenged with Leishmania donovani, a protozoa …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
Comparative Study
P.H.S.
Knockout
genetic predisposition to disease
chronic / complications
membrane glycoproteins / genetics
Chronic / genetics
granulomatous disease
membrane glycoproteins / physiology*
leishmania donovani / immunology*
leishmaniasis
visceral / immunology*
h w murray
liver / parasitology
nitric oxide synthase / deficiency
nitric oxide synthase / genetics
nitric oxide synthase type ii
chronic / immunology*
nadph oxidases / genetics
nadph oxidase 2
pmid:9989990
pmc2192937
doi:10.1084/jem.189.4.741
c f nathan
granuloma / etiology
granuloma / immunology
granuloma / parasitology
granuloma / pathology
visceral / complications
macrophage activation / physiology*
macrophages / parasitology
macrophages / physiology*
membrane glycoproteins / deficiency
nadph oxidases / deficiency
nadph oxidases / physiology*
nitric oxide / immunology*
nitric oxide synthase / physiology*
reactive oxygen species / immunology*
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Citation
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273285
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