Hypothermia is not neuroprotective after infection-sensitized neonatal hypoxic-ischemic brain injury
Abstract
Therapeutic hypothermia is not neuroprotective in this LPS-sensitized unilateral stroke-like HI brain injury model in newborn rats. Lack of neuroprotection was particularly seen in the hippocampus. Pre-insult exposure to LPS also induced brain area loss in the unligated hemisphere, which is normally …
Keywords
immunization
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
male
Disease Models
Animal
newborn
Rats
lipopolysaccharides
wistar
hippocampus / pathology
brain / pathology
escherichia coli
hypoxia-ischemia
hypothermia
induced*
pmid:24361672
doi:10.1016/j.resuscitation.2013.12.006
damjan osredkar
marianne thoresen
hemmen sabir
brain / etiology
brain / prevention & control*
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273177
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