PRDM16 controls a brown fat/skeletal muscle switch
Abstract
Brown fat can increase energy expenditure and protect against obesity through a specialized program of uncoupled respiration. Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myoge …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
gene expression regulation
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
N.I.H.
Extramural
cell line
DNA-Binding Proteins / metabolism*
Transcription Factors / metabolism*
adipose tissue
white / metabolism
developmental*
chlorocebus aethiops
skeletal / cytology
dna-binding proteins / genetics
transcription factors / genetics
ppar gamma / genetics
muscle
bruce m spiegelman
skeletal / metabolism*
cos cells
pmid:18719582
pmc2583329
doi:10.1038/nature07182
patrick seale
bryan bjork
adipocytes
brown / cytology
brown / metabolism*
cell differentiation* / genetics
muscle development / genetics
skeletal / growth & development
myogenic regulatory factor 5 / genetics
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Citation
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273104
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