Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19
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Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19

Chu, Hin;Chan, Jasper Fuk-Woo;Wang, Yixin;Yuen, Terrence Tsz-Tai;Chai, Yue;Hou, Yuxin;Shuai, Huiping;Yang, Dong;Hu, Bingjie;Huang, Xiner;Zhang, Xi;Cai, Jian-Piao;Zhou, Jie;Yuan, Shuofeng;Kok, Kin-Hang;To, Kelvin Kai-Wang;Chan, Ivy Hau-Yee;Zhang, Anna Jinxia;Sit, Ko-Yung;Au, Wing-Kuk;Yuen, Kwok-Yung;
clinical infectious diseases 2020 Vol. 71 pp. 1400-1409
142
hin2020clinicalcomparative

Abstract

The comparative viral kinetics, cell tropism, and innate immune response profiles of SARS-CoV-2 and SARS-CoV in human lungs were characterized in ex vivo organ

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