National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't adult female male Disease Models Animal case reports Child Clinical Trial phenotype syndrome hela cells heart failure / complications heart failure / drug therapy pmid:29899452 pmc7610773 doi:10.1038/s41586-018-0217-9 quitterie venot thomas blanc guillaume canaud class i phosphatidylinositol 3-kinases / antagonists & inhibitors* class i phosphatidylinositol 3-kinases / metabolism* lipoma / drug therapy* lipoma / enzymology* molecular targeted therapy* musculoskeletal abnormalities / drug therapy* musculoskeletal abnormalities / enzymology* nevus / drug therapy* nevus / enzymology* scoliosis / complications scoliosis / drug therapy sirolimus / therapeutic use thiazoles / therapeutic use* vascular malformations / drug therapy* vascular malformations / enzymology* vascular neoplasms / complications vascular neoplasms / drug therapy