Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
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Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

D Botstein, R L White, M Skolnick, R W Davis;D Botstein;R L White;M Skolnick;R W Davis;
American journal of human genetics 1980 Vol. 32 pp. 314-
134
davis1980americanconstruction

Abstract

We describe a new basis for the construction of a genetic linkage map of the human genome. The basic principle of the mapping scheme is to develop, by recombinant DNA techniques, random single-copy DNA probes capable of detecting DNA sequence polymorphisms, ...

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