Complex protein interactions within the human polyadenylation machinery identify a novel component
Abstract
Polyadenylation of mRNA precursors is a two-step reaction requiring multiple protein factors. Cleavage stimulation factor (CstF) is a heterotrimer necessary for the first step, endonucleolytic cleavage, and it plays an important role in determining the efficiency of polyadenylation. Although a consi …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
amino acid sequence
sequence alignment
P.H.S.
Molecular Sequence Data
Messenger / genetics
messenger / metabolism
nuclear proteins / metabolism
protein binding
proteins / genetics
proteins / metabolism*
rna-binding proteins / metabolism*
mrna cleavage and polyadenylation factors
rna-binding proteins / genetics
pmid:10669729
pmc85326
doi:10.1128/mcb.20.5.1515-1525.2000
y takagaki
j l manley
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272726
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