Infant Exposure to Dolutegravir Through Placental and Breast Milk Transfer: A Population Pharmacokinetic Analysis of DolPHIN-1

Infant Exposure to Dolutegravir Through Placental and Breast Milk Transfer: A Population Pharmacokinetic Analysis of DolPHIN-1

Dickinson, Laura;Walimbwa, Stephen;Singh, Yashna;Kaboggoza, Julian;Kintu, Kenneth;Sihlangu, Mary;Coombs, Julie-Anne;Malaba, Thokozile R;Byamugisha, Josaphat;Pertinez, Henry;Amara, Alieu;Gini, Joshua;Else, Laura;Heiberg, Christie;Hodel, Eva Maria;Reynolds, Helen;Myer, Landon;Waitt, Catriona;Khoo, Saye;Lamorde, Mohammed;Orrell, Catherine;DolPHIN-1 Study Group;Nakijoba, Ritah;Kyohairwe, Isabella;Magoola, Johnson;Ssempija, Emmanuel;
clinical infectious diseases 2021 Vol. 73 pp. e1200-e1207
112
laura2021clinicalinfant

Abstract

The population pharmacokinetic model described dolutegravir in maternal and infant plasma and transplacental and breastmilk passage. Based on infant elimination

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