Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen
Abstract
Dimeric derivatives (compounds 7 to 9) of the influenza virus neuraminidase inhibitor zanamivir (compound 2), which have linking groups of 14 to 18 atoms in length, are approximately 100-fold more potent inhibitors of influenza virus replication in vitro and in vivo than zanamivir. The observed opti …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
gel
animals
pubmed abstract
nih
national institutes of health
national library of medicine
male
Rats
Sprague-Dawley
cell line
microscopy
kinetics
electron
enzyme inhibitors / pharmacology*
orthomyxoviridae infections / prevention & control
chromatography
dogs
antiviral agents / pharmacology*
indicators and reagents
antiviral agents / therapeutic use
lung / metabolism
cytopathogenic effect
viral / drug effects
virus replication / drug effects
antiviral agents / administration & dosage*
structure-activity relationship
viral plaque assay
enzyme inhibitors / administration & dosage*
guanidines
neuraminidase / antagonists & inhibitors*
pyrans
zanamivir
sialic acids / pharmacology
orthomyxoviridae / drug effects
pmid:15561823
pmc529190
doi:10.1128/aac.48.12.4542-4549.2004
simon j f macdonald
keith g watson
simon p tucker
enzyme inhibitors / therapeutic use
orthomyxoviridae / enzymology*
orthomyxoviridae / growth & development
sialic acids / chemistry
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271839
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