Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival
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Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival

F Walter, J Schmid, H Düssmann, C G Concannon, J H M Prehn;F Walter;J Schmid;H Düssmann;C G Concannon;J H M Prehn;
Cell death and differentiation 2015 Vol. 22 pp. 1502-
206
prehn2015cellimaging

Abstract

An accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR) mediated via the activation of three transmembrane proteins IRE1, PERK and ATF6. Signalling through these proteins is aimed at enhancing ...

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DOI:
10.1038/cdd.2014.241
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc453277...

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