The emerging role of XBP1 in cancer

The emerging role of XBP1 in cancer

Chen S;Chen J;Hua X;Sun Y;Cui R;Sha J;Zhu X;;
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Vol. 127 pp. -
140
s2020biomedicinethe

Abstract

X-box binding protein 1 (XBP1) is a unique basic-region leucine zipper (bZIP) transcription factor whose dynamic form is controlled by an alternative splicing response upon disturbance of homeostasis in the endoplasmic reticulum (ER) and activation of the unfolded protein response (UPR). XBP1 was fi …

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