Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse liver preparations
Current Language EN
English English Türkçe Türkçe Español Español Português Português Pусский Pусский Filipino Filipino Tiếng Việt Tiếng Việt हिन्दी हिन्दी العربية العربية বাংলা বাংলা Deutsch Deutsch 中文 中文

Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse liver preparations

John K. Baker,Ronald F. Borne,W. Marvin Davis,I.Wade Waters;John K. Baker;Ronald F. Borne;W. Marvin Davis;I.Wade Waters;
Biochemical and biophysical research communications 1984 Vol. 125 pp. 484-490
141
waters1984biochemicalmetabolism

Abstract

Using a mouse liver microsomal preparation, it was found that the heterocyclic ring system of MPTP underwent an initial α-oxidation to give chemically reactive metabolites that may be associated with the induction of Parkinsonism by MPTP. Subsequent oxidative metabolic transformations of these intermediates were found to give a lactam metabolite and a pyridone metabolite that potentially may interact with the neurotransmitter system.

Keywords

induction neurotransmitter heterocyclic mptp methyl tetrahydropyridine phenyl lactam pyridone

Access

DOI:
10.1016/0006-291x(84)90566-7
URL:
https://sciprofiles.com/publication/view/cdc7fcb1b...

Citation

ID: 271545
Ref Key: waters1984biochemicalmetabolism
Use this key to autocite in SciMatic or Thesis Manager

References

References

No Bibliography

Blockchain Verification

Account:
NFT Contract Address:
0x95644003c57E6F55A65596E3D9Eac6813e3566dA
Article ID:
271545
Unique Identifier:
10.1016/0006-291x(84)90566-7
Network:
Scimatic Chain (ID: 481)
Blockchain Readiness Checklist
Authors
Abstract
Journal Name
Year
Title
5/5
Creates 1,000,000 NFT tokens for this article
Token Features:
  • ERC-1155 Standard NFT
  • 1 Million Supply per Article
  • Transferable via MetaMask
  • Permanent Blockchain Record
Blockchain QR Code
Scan with Saymatik Web3.0 Wallet
Gas fees required in SCI Coins
Buy SCI

Saymatik Web3.0 Wallet

Google Play
App Store