Oseltamivir is adequately absorbed following nasogastric administration to adult patients with severe H5N1 influenza
Abstract
In the absence of a parenteral drug, oral oseltamivir is currently recommended by the WHO for treating H5N1 influenza. Whether oseltamivir absorption is adequate in severe influenza is unknown. We measured the steady state, plasma concentrations of nasogastrically administered oseltamivir 150 mg bid …
Keywords
respiration
Gastrointestinal
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
pregnancy
treatment outcome
research support
non-u.s. gov't
adult
female
male
aged
Clinical Trial
Artificial
area under curve
viral load
influenza
human / drug therapy*
intubation
antiviral agents / therapeutic use
influenza a virus
oseltamivir / administration & dosage
h5n1 subtype*
pmid:18923671
pmc2565445
doi:10.1371/journal.pone.0003410
walter r j taylor
bui nghia thinh
nguyen gia binh
hemofiltration
h3n2 subtype*
oseltamivir / blood
oseltamivir / metabolism
oseltamivir / pharmacokinetics*
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271531
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