Histone acetyltransferases regulate HIV-1 enhancer activity in vitro

Histone acetyltransferases regulate HIV-1 enhancer activity in vitro

Philip L. Sheridan, Timothy P. Mayall, Eric Verdin, Katherine A. Jones;Philip L. Sheridan;Timothy P. Mayall;Eric Verdin;Katherine A. Jones;
genes & development 1997 Vol. 11 pp. 3327-
145
jones1997geneshistone

Abstract

Specific inhibitors of histone deacetylase, such as trichostatin A (TSA) and trapoxin (TPX), are potent inducers of HIV-1 transcription in latently infected T-cell lines. Activation of the integrated HIV-1 promoter is accompanied by the loss or rearrangement ...

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